Thomas Frank’s men are unbeaten in their last eight league games which include wins against giants Manchester City and Liverpool. They are currently eighth on the table with 30 points from 20 matches.
Southampton’s league form, on the other hand, has been woeful, with the Saints lying at the bottom of the Premier League table.
In the United States (US), Brentford vs Southampton can be watched on NBC and streamed live on Peacock TV.
The game between Southampton and Brentford is not being telecast in the United Kingdom (UK).
The match will be telecast on Star Sports Network in India.
Thomas Frank will be without Pontus Jansson and Frank Onyeka due to thigh and hamstring injuries, respectively, while Shandon Baptiste is doubtful for the tie.
Nathan Jones will be without players like Tino Livramento, Kyle Walker-Peters, Juan Larios, Moussa Djenepo and Alex McCarthy who are injured and unavailable for the match.