Barca travel to the Basque country to take on fourth-placed Real Sociedad on Saturday, while Real Madrid visit a resurgent Valencia side 24 hours later.
The Catalans, who sit ahead of their great rivals on goal difference with both on 34 points.
They were able to rest a number of first-team regulars including Lionel Messi in Tuesday’s 2-1 UEFA Champions League victory over Inter Milan, having already qualified for the knockout stages.
After a difficult start to the season, Barca have lost just one of their last 16 matches in all competitions.
Coach Ernesto Valverde feels they are clicking into gear at the right time.
“We’re in a good way. It’s good to see this kind of consistency. We had to come through a difficult spell to get to where we are now.
We had difficulties, with a number of forwards injured and they had to try and get back into form on the hoof, with little time.
“We always have to win at this club, the players know and feel it. We are really happy with how things are going and we’ve shown once again that we always want to win, whoever we play ,” he said.
Saturday’s opponents Real Sociedad have stumbled slightly of late after topping La Liga at the start of November.
They have won just two of their last six matches to slip to fourth, seven points off the table-toppers.
Meanwhile Real Madrid, who have won eight of their last 10 in all competitions, travel to a buoyant Valencia.
Valencia secured an unlikely berth in the last 16 of the UEFA Champions League with an impressive victory away to Ajax Amsterdam in midweek despite missing nine first-team regulars through injury.
Real Madrid coach Zinedine Zidane faces a difficult decision on whether or not to rest midfield general Casemiro for the trip to Mestalla.
The Brazilian has started in all of the club’s La Liga matches this season.
But he is a yellow card away from missing Wednesday’s Clasico through suspension having picked up four bookings already this campaign.
He’s played (in the UEFA Champions League) and we’ll have a look into it for the next game, and see what we do in Valencia. He hasn’t got much rest, but I’m not going to say what my plan is.
Third-placed Sevilla will hope to take advantage if either of the top two slip up when they host Villarreal.
Atletico Madrid will host Osasuna and Eibar also visit Athletic Bilbao in a Basque derby.
(Edited by: Olawale Alabi)
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