1 Chinese scientists have designed a hydrogel that might have a double effect in the fight against cancer, burning up tumors more accurately and boosting one’s anti-tumor immunity.
2 The study published on Thursday in the journal Science Advances described the metal-based biomaterial that was shown to enhance the heating efficiency and restrict the heating zone under microwave exposure, a local tumor ablation strategy used clinically.
4 According to the scientist, this can produce more heat in a restricted, targeted spot and avoid causing thermal damage to nearby healthy tissues.
5 The study said the existence of excess extracellular calcium ions was shown to sensitise cancer cells to mild thermal damage, thus promoting complete ablation of the primary tumor.
6 “Then, those cancer cells burnt to death will further work together with calcium and manganese ions to prime effective innate and adaptive anti-tumor immune responses.
The paper’s co-corresponding authors with Soochow University, Feng Liangzhu and Liu Zhuang said the molecular pathways activated in this mechanism could suppress the growth of both metastatic and relapsed tumors.
8 The researchers were re now exploring the possibilities of clinical translation, said Feng. (